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While most studies revealed that codon 87 of gyrA gene represents the most frequently mutated amino acid in Salmonella [ 8, 12, 14], point mutations outside of QRDR may also play a role in quinolone-resistance [ 6].
Thus, it seems that a mutation or mutations outside of the prion gene can generate prion-like pathology.
They allow you to perform DOM mutations outside of the actual DOM and then simply apply a patch from your virtualised DOM to the real DOM.
This is the case in Alzheimer's disease, in which there are mutations outside of the gene encoding the amyloid precursor protein.
However, between 40% and 60% of cases arise from the accumulation of what appear to be random mutations outside of known driver genes.
On the other hand, WGS greatly increases the number of background/passenger mutations under consideration and faces unique challenges such as associating mutations outside of coding regions with specific effects.
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The probable mutations are ranked starting from the most likely to be pathogenic according to the following list: nonsense, frameshift, essential splice site (affecting the conserved consensus intronic positions), start loss, stop loss, missense, predicted splice site mutation (outside of the consensus sites), in frame indels, and synonymous coding.
Although some research is warranted, they say, there is no need to share the mutation data "outside of a small select group of established researchers already working within the WHO network .The WHO, for its part, said in a statement to Science that research like that of Dr Fouchier and Dr Kawaoka is "an important tool for global surveillance efforts".
Although some research is warranted, they concede, there is no need to share the mutation data "outside of a small select group of established researchers already working within the WHO network".Such work, say many, should only be done in the most secure facilities: those rated "biosafety level 4".
Similar to our TILLING assay in barley, neither homozygous nor heterozygous lines with mutation outside of the AP2/ERF domain (26 lines) displayed a branched spike.
Because this tumor had deleted the mutant allele (Table 2), this finding implies that a somatic TP53 mutation outside of exon 10 was acquired during tumorigenesis.
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