Sentence examples for mutations or functionally from inspiring English sources

Other features may simply reflect accidental mutations or functionally neutral changes in the genetic code.

In particular, the algorithms for predicting the functional effect of missense variants estimate the probability that a mutation is disease-associated or functionally deleterious.

In our study, 4 out of the 6 positively staining samples were correlated with p53 LOF mutations (see below) while 11 out of the 16 negatively staining samples were correlated with no or functionally equivalent mutations (Table 4).

However, the question arises as to whether there are similar (or functionally related) mutations in RA.

The 7 CC samples clustering within the A-L group had either no mutations or were associated with functionally silent mutations in p53 gene.

After duplication, both copies continue functioning when natural selection favors duplicated protein function or expression, or when mutations make them functionally distinct before one copy is silenced.

Overall current FLT3 receptor molecular tests provide no information about the functional consequences of these mutations on intracellular signaling pathways and do not detect the presence of other functionally related mutations or alterations that may cause deregulation of FLT3 receptor pathway activity.

Protein families evolve functional variation by accumulating point mutations at functionally important amino acid positions.

The Keap1-Nrf2 signaling pathway is impaired in lung cancer, which is caused by mutations within functionally important domains of the KEAP1 or NRF2 gene [ 15- 17].

Theoretical studies suggested that higher proportions of neutral mutations (i.e., greater relaxed constraint) can result from whole-genome duplication due to the reduction of Ne or due to the masking of deleterious mutations by functionally redundant gene copies15,16.

In contrast, collections of nonsynonymous polymorphisms or cis-regulatory polymorphisms are likely to contain many positions at which mutations are functionally neutral, leading to an underestimate of the strength of selection at functionally critical sites.