Sentence examples for mutations or functional from inspiring English sources

Dysregulation of the alternative pathway of complement may occur as a result of mutations or functional inhibition of complement-regulating proteins.

So inactivation of p53 in precancerous cells with BRCA mutations or functional abnormalities would avoid apoptosis and lead to cancer in association with other somatic mutations.

Mutations or functional impairment of such common TFs may affect the expression of the three genes, which may result in disease phenotype.

Therefore, these results indicate that changes in the status of p53 due to mutations or functional inactivity change the sensitivity to TS inhibitors by altering the expression and activity of TS.

Since BRCA1 is also involved in DNA repair and genomic stability, it has been proposed that BRCA mutations or functional abnormalities would result in accumulation of genetically unstable mammary stem cells and thus a step towards breast cancer [ 15, 16].

Second, mutations or functional polymorphisms in steroid nuclear receptors cause or are associated with breast cancer [ 26- 30]; for example, a germline mutation in the AR gene was reported as the causation of breast cancer in two brothers [ 31].

The MET signaling also can be aberrantly activated as a consequence of MET mutation or functional single nucleotide polymorphisms (SNPs).

However, such resistance can be broken within a few years of release [ 7, 8], mostly due to the mutation or functional loss of the Avr genes.

Weaker phenotypes could arise either through a reduced frequency of induced indel mutations or because functional in-frame mutations at the specific gRNA target site provide a significant fraction of cells with functional protein.

Mutations in MPZ, SOX10, and EGR2 have been implicated in demyelinating peripheral neuropathies, suggesting that components of this transcriptional network are candidates for harboring disease-causing mutations (or otherwise functional variants) that affect MPZ expression.

However, most previous studies focused on either LoF or GoF mutations or on functional changes in a specific gene.