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For example, synonymous cancer terms from different databases mapped to specific DO terms can be used to collapse hundreds of terms across many databases into a few top-level cancer types that can then be used to identify mutations or expressions across multiple cancers (17, 40).
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Pathological information on mutational status of RTK and p53 mutations or expression levels of key signalling molecules, such as EGFR, HER-2 and HIF-1 expression, should also be obtained to select appropriate patient populations.
Prognostic and predictive biomarkers can be used to tailor chemotherapy treatments based on gene mutations or expression resulting in increased patient survival.
It is possible that mutations or expression levels of NM23 that result in dimers as the major species could drive cell growth by stimulating the MUC1* receptor for prolonged periods of time.
However, high levels of 2-HG were not associated with somatic mutations or expression levels of IDH1 or IDH2.
However, none of these studies established associations of particular metabolites or metabolic pathways with specific somatic mutations or expression levels that have been extensively characterized in TCGA.
Regorafenib, which is multikinase inhibitor, suppressed proliferation in all the cell lines irrespective of KRAS, BRAF, PIK3CA, and TP53 mutations or expression.
The absence of pathogenic coding mutations or expression deregulation in this set of familial cases indicates that BCoR-L1 is extremely unlikely to be a major high-risk familial breast cancer predisposition gene.
Also, prior to examining these cases for promoter mutations or expression defects, reviewing the patient and family history is strongly recommended in order to investigate the possibility that other genes are involved.
No mutations or expression changes of the Bcl-G gene were found in children with acute lymphoblastic leukaemia, but a TEL AML1 fusion transcript involving BCL-G was reported in another.
Mutation or expression data of imatinib targets were not available.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com