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Pathological information on mutational status of RTK and p53 mutations or expression levels of key signalling molecules, such as EGFR, HER-2 and HIF-1 expression, should also be obtained to select appropriate patient populations.
However, high levels of 2-HG were not associated with somatic mutations or expression levels of IDH1 or IDH2.
Prognostic and predictive biomarkers can be used to tailor chemotherapy treatments based on gene mutations or expression resulting in increased patient survival.
It is possible that mutations or expression levels of NM23 that result in dimers as the major species could drive cell growth by stimulating the MUC1* receptor for prolonged periods of time.
However, none of these studies established associations of particular metabolites or metabolic pathways with specific somatic mutations or expression levels that have been extensively characterized in TCGA.
Regorafenib, which is multikinase inhibitor, suppressed proliferation in all the cell lines irrespective of KRAS, BRAF, PIK3CA, and TP53 mutations or expression.
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Mutation or expression data of imatinib targets were not available.
This molecular testing typically involves mutation or expression analysis of nucleic acids or protein recovered from FFPE tissue sections.
They do not, however, support a model in which mutation or loss of expression of CHK2 might functionally substitute for inactivation of p53 via mutation or expression of HPV E6.
Users upon downloading data from any of the cancer genomics databases supported by this project can replace the source terms with DOIDs and DO cancer terms prior to analysis of mutation or expression data from these source databases.
To our knowledge there has been no previous report of any genetic mutation or expression change that occurs with such high frequency among patients in a variety of cancers.
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