Sentence examples for mutations or expressed from inspiring English sources

In contrast, none of our tumors harbored either mutations or expressed promoter hypermethylations affecting the p14.

In brief, significantly altered chromosomal segments based on copy number analysis were filtered based on nucleotide variant information and aberrant expression of transcripts to allow prioritization of regions harboring either deleterious mutation or expressing the transcript at significantly high levels, in addition to the stringent intrinsic statistical mining performed for each sample.

The more organized a system is, the more sophisticated are the mechanisms that bias the way in which tensions are released by mutations or the way in which these mutations are corrected or expressed to increase complexity.

We and other groups have successfully elucidated various aspects of NAFLD and NASH induction by using zebrafish and medaka that have naturally occurring or engineered mutations of certain genes, or express engineered transgenes.

Most of these mutations were expressed as frameshifts or splicing errors and resulted in no or very little IL2RG mRNA being expressed as shown in Figure 1d probably due to nonsense-mediated decay.

Using stereotaxic adenoviral delivery targeted to a large portion of the VMH, AMPKα isoforms carrying either dominant-negative (DN) or constitutively active (CA) mutations were expressed.

The importance of intermediate filaments in muscle is further strengthened by murine models in which genetically designed intermediate filament mutations are expressed, leading to progressive skeletal or cardioskeletal myopathy in affected mice.

These "polymerase stabilizing" mutations are expressed in HBsAg close to or in the "a" determinant and reduce HBsAg immunoreactivity (40 ).

Among those, no channel activity was observed for mutations Ser229Pro, Gly1018Arg, Arg1060Trp and Leu1079Pro mutations expressed in Xenopus laevis oocytes (Ser229Pro, Leu1079Pro, [51]) or tsA-201 cells (Gly1018Arg, Arg1060Trp [81]) although their α1 subunits were expressed at levels indistinguishable from wildtype channels.

Interestingly, expression levels of Fra-2 containing S320A and/or T322A mutations were expressed at lower levels in addition to the loss of the slower mobility (High-Mr) band.

This fact is interpreted as different opportunities for selection against deleterious mutations among fitness components because deleterious mutations expressed at the early life-cycle stages are more frequently purged from inbred populations than those at late life-cycle stages (Husband and Schemske, 1996).