Sentence examples for mutations or are from inspiring English sources

Further work is necessary to determine whether these two haplotypes capture ancestrally distinct causative mutations or are in linkage disequilibrium with a single disease-causing mutation.

One possibility is that mtDNA deletions in these patients are inherited from maternal germ line mutations, or are acquired during early embryogenesis, while the mtDNA deletions in older age groups represent later somatic random events.

The data are remarkable in that most of the mutations, including dpol and dplv mutants, result in stop codons either at the site of the mutations or are generated from a deletion, or cause the removal of a splice site.

We have created Additional file 2 (line 219) to clarify whether these genes have stop codons, frameshifts, or mutations or are replaced with other genes.

These transplanted cells are modified ex vivo to contain tumor-initiating mutations or are derived from tissues of tumor-prone mice.

TP53 mutations that affected the coding region were detected in 5 (9%) tumours, all of which are either previously described pathogenic mutations or are predicted to be pathogenic.

All the substitutions in the coding region were found most likely lacking any phenotypic effect, because they are conservative mutations or were not part of the transmembrane domain.

The 7 CC samples clustering within the A-L group had either no mutations or were associated with functionally silent mutations in p53 gene.

These may arise as spontaneous mutations, or be transmitted from parent to child.

They were carriers of either translocation or inversion mutations, or were patients with recurrent miscarriage and/or advanced maternal age.

Participants will not be told whether they have the mutation or are receiving the drug.