Sentence examples for mutations or amplification from inspiring English sources

We propose that other tumors that possess somatic autoactivating mutations or amplification in non-receptor tyrosine kinases could use similar mechanisms for AKT activation [37].

The presence of AR expression, somatic AR mutations or amplification does not necessarily mean, however, that a prostate cancer cell is addicted to AR signaling.

Oncogenic mutations or amplification of Ras results in VEGF upregulation.

The Kaplan-Meier method was used for survival analysis grouping with PIK3CA mutations or amplification.

Correlation between PIK3CA mutations or amplification and clinicopathological characteristics was analyzed by Fisher's exact test or Pearson's Chi square test.

Mutations or amplification of genes encoding transporters or target enzymes have been identified as resistance mechanisms to other antimalarial drugs.

Several mutations or amplifications occur in genes for the RTKs: EGFR, ALK, MET, ROS1, RET, FGFR1 and DDR2 or in genes that help facilitate RTK downstream signaling events such as: KRAS, BRAF, and PIK3CA (phosphoinositide-3-kinase (PI3K) family member) in NSCLC [9 13].

In addition, mutations or amplifications of Pfmdr-1 gene can play a significant role in P. falciparum resistance to diverse antimalarials such as mefloquine, quinine or artemisinin derivatives [10].

Double-negative BRAF and N-RAS melanomas should be further explored for KIT mutations or amplifications.

Mutations or amplifications in ERRB2 were also identified in 9% of patients 35.

Subsequently, somatic ALK mutations or amplifications were identified in about 8% of all sporadic NB tumors [ 59- 63].