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Females' "spare" X chromosome protects them from genetic mutations on the other one.
In addition, we rationalize the influence of nucleotide mutations on the equilibrium position of one of the bistable RNA sequences.
This disulfide bond involves two mutations on the extracellular side: PS1(Q112C) and Notch(P1728C).
These changes are representative of the dominant-negative effects of SMARCA4 mutations on the enhancer landscape.
Sutto, L. & Gervasio, F. L. Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase.
To test the equilibrium hypothesis we examined the effect of mutations on the kinetics of particle interactions.
The effects of stabilising mutations on the folding process of common-type acylphosphatase have been investigated.
Even mutations on the periphery of the core can tip the balance between alternatively folded states.
The effects of mutations on the affinity of the large subunits for SSUs also vary.
In addition, some immune escape mutants carrying mutations on the S antigen were reported.
Two others had de-novo mutations on the same gene, which meant that the Duke team had likely discovered the genetic basis of a new disorder.
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