Sentence examples for mutations on cell from inspiring English sources

Hence, the effect of somatic mutations on cell fitness was dependent on the whole mutation burden, not only on expressed regions.

The analysis of genes associated with cell functions provides new insight into consequences of FGFR3 mutations on cell cycle regulation, onset of pre-hypertrophic differentiation, concomitant metabolism changes and adhesion.

Excess cell division is postulated to be a primary cause of these 'neoplastic' phenotypes, but the autonomous effect of these mutations on cell cycle control has not been examined.

Recent studies include the investigation of the effects of ERBB2 overexpression on cell invasion [4], deletion of RB on the epithelial-to-mesenchymal transition (EMT) [5], and PCDH8 mutations on cell transformation [6].

Thus, the consequence of these FOXC1 mutations on cell viability was examined.

To determine the effect of P69L and W76X mutations on cell growth, we performed a clonogenic assay using p27-negative GH3 cells.

Impact of the PRKD1 p.Glu710Asp mutation on cell migration and cell growth.

Thus, although C57BL/6 and 129S6 MOR-1 KO mice both exhibit increased cell proliferation in the DG, the impact of the MOR-1 mutation on cell survival differs between strains.

Our results indicate that the effects of the slr1 mutation on cell size were comparable between the wild-type and pla1 backgrounds.

It will be of great interest to examine the status of IRF-5 mutation in human cancers and the role of this mutation on cell growth and apoptosis.

Moreover, the positive effects of FHL2 mutation on cell migration in ApcΔ14/+FHL2−/− mice correlate with the observation that FHL2 deficiency perturbs essentially adenoma initiation.