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Exact(15)
In contrast, the mutator alleles produced ∼2- to 10-fold more mutations on average.
Seven beneficial mutations on average were necessary to improve the relative fitness from 1.0 to 1.43 and the model was consistent with the population biology and the genetic data of 12 experimental lines.
Because approximately 3000 clones are needed to cover 1.5 mutations on average, we harvested ∼10,000 E. coli colonies for the sublibrary, which we named sublibrary 9.1.
A difference in complexity was also found at the gene level, assessed as mutation index: in the older group each patient had 1.5 mutations on average, compared to 1.0 in the younger age group.
After these filtering steps, 1,516 proteins remained, which contained altogether 22,416 missense mutations (on average 14.8 per protein).
The 98 sequences in this subfamily differ from the consensus sequence by 2.622 mutations, on average, at non-CpG sites.
Similar(45)
However, we estimate that 20 days of consecutive bottlenecking should be required to fix roughly one mutation, on average.
The estimated genomic mutation rate in phage ϕ6 is gauged to be 0.067 deleterious mutations per generation [ 43], causing one mutation on average to fix in a lineage after 20 bottlenecks (i.e., 0.067 × 20 bottleneck events ≈ 1.3), where the majority of spontaneous mutations are assumed to be deleterious.
For example, a 9 bp homopolymer experienced a mutation, on average, every 8 generations (0.13 per generation per run).
The combined frequency of mutations adding genes to the population (gene transfer, duplication and insertion) was approximately 10% lower than the frequency of deletions, so that mutation on average results in slightly less complex organisms.
Both diseases showed overall low somatic mutation rates (on average 4.6 mutations per exome); mutations identified in pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma were seen in pathways important for transcription, intracellular signaling and cellular organization.
More suggestions(15)
mutations on secondary
mutations on dance
mutations on cohesion
mutations on disease
mutations on delivery
mutations on spindle
mutations on protein
mutations on biotinyl-lysine
mutations on serine
mutations on pathogenicity
mutations on sister
mutations on survival
mutations on cDNA
mutations on interferon
mutations on transcription
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