Sentence examples for mutations offer a from inspiring English sources

Due to their clustering around positions 21 23, these mutations offer a unique opportunity to correlate toxicity to specific aggregate conformers, as point mutations alter the rates of Aβ aggregation, fibril formation, interaction with surfaces, and insertion into lipid bilayers by changing the hydrophobicity or charge following substitution.

Our study provides evidence that spliceosome gene mutations offer a means to exploit age-related changes in hemopoiesis to drive clonal hemopoiesis in advanced old age, an observation that blurs the boundary between "driver" and "passenger" mutations.

We reasoned that this could serve as an estimate of whether mutations accumulate over time during the culturing of tumor cell lines, which in turn may indicate whether such mutations offer a growth advantage in vitro.

Therefore, the formation of new eh1-like motifs through the accumulation of missense mutations offers a convergent mechanism for multiple independent appearances of the motif in the Fox family.

In addition the finding of a relative reduction of COQ10 in muscle (levels between 10 and 20 μg/g) in patients which are negative for ADK3 mutations offers a possible clue for subgrouping conditions of CA and CHA of undetermined cause.

This is plausible, but it does not consider the possibility that the mutations offered a selective advantage, perhaps by reducing reactive oxygen production, or by fine tuning stress response regulation via effects on hypoxia inducible factor 1α, or by noncoding effects of the gulonolactone oxidase pseudogene (De Tullio 2010; Johnson et al. 2010).

In addition, the identification of asymptomatic carriers of such mutations offers an unprecedented opportunity for OC prevention.

Analysis of such mutations offers an opportunity to characterize the genetic and developmental bases of a novel trait not represented in classical model organisms (e.g., [ 17, 18, 38- 41]).

With an increasing amount of both protein structural data in the PDB database and somatic mutation data generated by next-generation sequencing (NGS) experiments, the integration of protein structural information and large-scale somatic mutations offers an alternative, promising approach to uncovering functionally important somatic mutations in cancer.

We reasoned that the F266A mutation offered an experimental strategy to isolate the requirement of lncRNA binding for WDR5 function.

Although the role that this gene plays in a sulfate-limited environment has yet to be elucidated, its positive effect on fitness under sulfate-limiting conditions strongly suggests this mutation offers an alternative adaptive trajectory to this strong selective pressure.