Sentence examples for mutations off from inspiring English sources

Sequence space is defined by a set of allowed mutations off a base sequence, per sequence position, per residue.

Yet many mutations switch off genes or make products that do nothing at all.

Some in this camp saw innovation in strict Darwinian terms, with random mutations throwing off a wide diversity of solutions and the unfit ones being weeded out by the marketplace.

The researchers wondered if unregulated mutations set off by repeated infections later in childhood could make the difference, triggering the leukemia.

"The two mutations set off a positive feedback loop in specific tissues that amplified lifespan," Kapahi said.

A number of studies [ 3, 27, 28] have observed that the probability that a protein remains functional after m mutations falls off exponentially with the number of mutations.

Similarly, population methods find the distribution of slightly deleterious mutations falling off leptokurtically, that is, more rapidly than exponentially (such as in a gamma distribution with α < 1) (Eyre-Walker et al. 2006), while evolutionary models often yield a more rounded distribution (α > 1) (Nielsen and Yang 2003; Rodrigue et al. 2010).

Norman (1975) derived an alternative approximation to the Wright Fisher process, known as the Gaussian diffusion, in which the effects of selection and mutation die off less rapidly compared to genetic drift as the population size gets larger and the selection and mutation parameters tend to zero.

We also assessed whether whole-exome sequencing could be used to identify mtDNA mutations from off-target reads derived from the mitochondrial genome.

It was possible to efficiently mutate all 11 loci chosen for testing; only two of the targeting vectors resulted in detectable off-target mutations at predicted off-target loci.

For the 2A site, we also crossed the y mutation off of the M{ ry 609N} and crossed ec onto the M{ ry 606N} chromosome.