Sentence examples for mutations of the second from inspiring English sources

The reported mutations of the second allele were missense mutations.

Here we present the results of mutations of the second glutamyl residue involved in zinc coordination and of a tyrosine and a phenylalanine residues that occupy critical positions within the active site of BoNT/A.

Intron2 of the Tbx5 gene with mutations of the second Hox-binding site was used to induce Cre expression broadly in the LPM (Nishimoto et al., 2014).

Such mutations are internal tandem duplications of the juxtamembrane domain (ITD), point mutations of the juxtamembrane domain, or point mutations of the second tyrosine kinase domain (TKD).

In ovarian cancer, loss-of-heterozygosity (LOH) at the PTEN locus (10q23.3) occurs in 31 45% of tumours, whereas mutations of the second PTEN allele are relatively rare (Maxwell et al, 1998; Obata et al, 1998; Kurose et al, 2001).

Mutations of the second, third or fourth most proximal AAAAG site (hereinafter referred to as DOF2, DOF3 and DOF4, respectively), resulted in a reduced GUS expression, although to a lesser extent than the one in the DOF1.

Mutations of the third gating charge (R3) cause normokalaemic periodic paralysis5 owing to cation leak in both activated and inactivated states6.

Mutations of the first two residues within this motif usually alter receptor function and, when they occur naturally, can even cause diseases.

Earlier studies of the sigma subunit-DNA interaction [47], [48] demonstrated that mutations of the third G of the −35 hexamer to either A or C, but not to T, were suppressed by the substitution of Arg588 in region 4 of σ70 with His.

Fierke, Christianson, and others found that mutations of the first shell of CA generally led to large (∼1000-fold ∼1000-fold in activity while mutations of the secondecreasesinactivityHis94 and His119 resulted in moderately (3−10-fold) lowhilecat/ Kmutationsbut, depending of the mutation, could modulate the p Ka of the zinc water/hydroxide nucleophile.

The bovine NCBI sequence showed significant mutations of the third conserved domain marked in red on the alignment.