Sentence examples for mutations of the four from inspiring English sources

For example, mutations of the four positively charged residues, R1639G, R1642S, R1645Q, and R1648C, are present in the domain IV S4 segment (Table 2), suggesting that these EIEE6 mutations may alter the voltage sensing behavior of the channel.

This fragment was replaced with a synthesized fragment that contained mutations of the four consensus sites at T386, S416, S441, and S447 to alanines (pTE13).

Individual or coupled mutations of the four cysteines of RhCG did not render the ammonium transport mediated by RhCG recombinant cells mercury-insensitive (N.Z-Y, unpublished data), indicating that Hg2+ does not interact with the cysteine residues of RhCG.

No mutations of the four genes were found in BM from breast or kidney.

Individual mutations of the four predicted N-linked glycosylation sites (N100A, N148T, N248E, N383E) showed that glycosylation of Asn 148 and Asn 248 was required for protein solubility.

Despite the mild phenotype in mice, mutations of the four subunits of AP-4 in human all caused HSP (hereditary spastic paraplegia), a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness, with or without other neurologic abnormalities [ 72– 76].

Mutations of the two Cys residues can significantly impair the binding ability of hCutC with Cu(I).

Nonetheless, simultaneous mutations of the three LRR-RKs genes (pxy-3 with pxl1 and pxl2) generated an enhanced vascular phenotype observed in pxy-3 plants with flatter vascular bundles and a less clear distinction between xylem and phloem.

Somatic mutations of the two genes coding for the histone acetyltransferase genes, CREEBP and EP300 have been identified as a pathogenetic mechanism shared by common forms of B-cell non-Hodgkińs lymphomas.

As shown in Figure 3B, FBS and WY-14643 efficiently induced CYP1A1 promoter transactivation (2.5-fold) while the mutation of one PPRE site alone slightly reduced luciferase activity, and the mutations of the two PPRE sites abrogated it.

In contrast, mutations of the miR-128 and 27a/b binding nucleotides 14 and 236 of the 3'-UTR relieved the miR-mediated repression of luciferase activity.