Sentence examples for mutations of the first from inspiring English sources

Mutations of the first two residues within this motif usually alter receptor function and, when they occur naturally, can even cause diseases.

Disruption of either the putative stems or loops of the repeat A abrogated silencing, and mutations of the first palindrome to enforce pairing within a repeat, or between the first and second repeat, supported models that the first palindrome forms a hairpin.

Fierke, Christianson, and others found that mutations of the first shell of CA generally led to large (∼1000-fold ∼1000-fold in activity while mutations of the secondecreasesinactivityHis94 and His119 resulted in moderately (3−10-fold) lowhilecat/ Kmutationsbut, depending of the mutation, could modulate the p Ka of the zinc water/hydroxide nucleophile.

Furthermore mutations of the first amino acid of a cbEGF domain of coagulation factor IX in haemophilia B have been proven to reduce calcium binding even if the aspartic acid is replaced by the acidic amino acid glutamic acid (Handford et al., 1991; Winship and Dragon, 1991).

For example, mutations of the first arginine in domain II, II-R1, as well as II-R2 and III-R2 mutations generate omega currents that are activated by hyperpolarization, are active at the usual resting potential, and are only closed by depolarization large enough to activate S4 (Sokolov et al., 2007; Struyk et al., 2008; Sokolov et al., 2010; Francis et al., 2011; Wu et al., 2011).

Here we present the results of mutations of the second glutamyl residue involved in zinc coordination and of a tyrosine and a phenylalanine residues that occupy critical positions within the active site of BoNT/A.

Earlier studies of the sigma subunit-DNA interaction [47], [48] demonstrated that mutations of the third G of the −35 hexamer to either A or C, but not to T, were suppressed by the substitution of Arg588 in region 4 of σ70 with His.

The bovine NCBI sequence showed significant mutations of the third conserved domain marked in red on the alignment.

Such mutations are internal tandem duplications of the juxtamembrane domain (ITD), point mutations of the juxtamembrane domain, or point mutations of the second tyrosine kinase domain (TKD).

Intron2 of the Tbx5 gene with mutations of the second Hox-binding site was used to induce Cre expression broadly in the LPM (Nishimoto et al., 2014).

Mutations of the second, third or fourth most proximal AAAAG site (hereinafter referred to as DOF2, DOF3 and DOF4, respectively), resulted in a reduced GUS expression, although to a lesser extent than the one in the DOF1.