Sentence examples for mutations of substantial from inspiring English sources

This model suggests that in a population barely capable of exploiting an opportunity, which lacks better competitors, mutations of substantial effect, would have a meaningful chance of being favorable in the opportunity-rich Cambrian world, even though in today's competitive world they would be disasters.

Recently, there has been a surge in interest in the cancerization field theory of carcinogenesis, which states that as a result of exposure to carcinogens and/or of inherited genetic variants (mutations), a substantial portion of an organ (called the field) can be enriched in genetic variants of cells, which then may or may not acquire further genomic modifications.

While we have no such information for other correlates such as longevity, number of broods per life, offspring survival, etc., our current limited evidence suggests that P. formosa experiences only little or no genomic decay despite our predictions of substantial deleterious mutation accumulation.

The combined frequency of TSC1/TSC2 mutations of 15% indicates that a substantial proportion of UC tumors may show activation of mTOR through TSC1 or TSC2 mutational inactivation.

Taken together, these findings indicate that mutations of mitochondrial genome play a substantial role in the development of atherosclerosis.

We have found a number of substantial differences in context-dependent mutation regularities of Mus musculus and Homo sapiens.

This approach provides a very high-resolution view of the dynamics of individual mutations, leading to substantial insight.

Hexamers with two WA or WB mutations showed substantial recombination activity (∼65% of wild type in 1 min reactions), whereas the mixed subunit population that gives hexamers with a single mutation (50%) showed at least wild-type activities after correction for the wild-type (25%) and double-mutated (25%) population.

The current study describes identification of substantial levels of SDHB transcripts carrying a recurrent R46X mutation in normal PBMCs.

Furthermore, all seven mutations showed substantial positive effects at the final stage of their introduction (six-point mutants of LinBUT, Figure 5a).

All of these mutations might have substantial impact on phosphorylation and gating properties of the channel.