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A normal trafficking but absent enzymatic function characterizes mutations of phenotype III.
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It is interesting to note that the effect of mutations on phenotype does not have any particular sensitivity to this important threshold.
Substantial alternation by mutation of phenotypes governed by QTLs has been reported in other plants as well.
While closest to multifunctionality in definition, pleiotropy (the ability of a gene to influence multiple phenotypic traits) is not typically used to refer exclusively to molecular traits and is usually defined with reference to the effect of mutation on phenotype.
These results suggest that thorough and labour-consuming study of mutation-induced behavioural phenotype is necessary not only in different genetic backgrounds but also the substantial variation of phenotype due to sex- and environment-related factors have to be explored.
Very little is known about the effects of BRCA1/2 mutations on phenotypes other than cancer.
It has been widely accepted that the impact of a specific mutation on phenotype will depend on the genetic background.
We developed a machine learning strategy to link the effects of VHL missense mutations to phenotype.
We use predictions from in silico tools to link the functional effects of missense VHL mutations to phenotype.
Although the percentage of transversion mutations was relatively low in both genomes, they should not be omitted in a mutation study because they potentially are causal mutations for phenotypes of interest.
Effects of SNPs on coding and noncoding regions could be manipulated to identify a causal mutation of a phenotype of interest.
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