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Transitions between networks and mutations of networks are defined by exchanges of single reactions.
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Furthermore, KEGG does not provide any mutation information and the effect of mutation on networks could not be evaluated with KEGG.
We organize this presentation into five main categories, denoting the kinds of problems being addressed by the various studies: identifying dysregulated pathways, elucidating consequences of mutations on network activities, integrating network operation into cell behavioral functions, integrating cell behavior into tissue-level processes and predicting effects of molecular interventions.
To further explore the functional roles of pocket mutations on network level, we investigated the gene co-expression distribution for gene-gene pairs harboring pocket mutations.
The mutations of the network also have a marked effect on the kinetics of transport, indicating that cytoplasmic network formation is a fundamental step in the transport cycle of the mitochondrial ADP/ATP carrier.
However, our analysis still provided statistically significant characteristics of somatic mutations and networks of TSGs and OCGs.
Therefore, regulatory mutations likely affect hundreds of networks in each genotype, and quite a few of them many times.
Impaired glycerol flux was also observed for mutations of H80-interaction network residues, S77 and R94 (both profoundly affected) and F85A (moderately influenced).
There was a marked effect on the Vmax of transport caused by mutations of the cytoplasmic network.
We investigated the effect of the mutations of the cytoplasmic network on the transport rate in fused membrane vesicles of Lactococcus lactis [29] by monitoring the specific initial rate of exchange of internal unlabeled ADP for external labeled C-ADP (Fig. 5 and Fig. S2).
In simulated evolution of populations of networks, single mutations in regulatory or coding regions resulted in multiple changes in regulatory connections among genes, or alternatively in neutral change that had no effect on phenotype.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com