Sentence examples for mutations of many from inspiring English sources

The causative mutations of many patterns remain unknown.

Human homolog mutations of many genes with photoreceptor-associated expression have been shown to be associated with retinal diseases including RP [27].

Over-expression as well as both activating and inactivating mutations of many KMTs correlate with cancer [16].

A recent review by Baylin and Ohm [ 18] have demonstrated that epigenetic events may lead to LOH and mutations of many genes which may further underline the importance of epigenetic mechanisms in cancer initiation and progression.

Mutations of many genes have been newly described in patients with malformations of cortical development and these, along with the new advances concerning normal development discussed in the previous section, form the basis for this update.

Indeed, the role of this pathway in tumorigenesis has been extensively investigated and altered expression or mutations of many components of this pathway have been implicated in human cancer (Vivanco and Sawyers, 2002).

The Cre-loxP system has been used to enable tissue specific activation, inactivation and mutation of many genes in vivo and has thereby greatly facilitated the genetic dissection of several cellular and developmental processes.

Indeed, systematic mutagenesis of identified phosphorylation sites showed that mutation of many phosphorylation sites affects FRQ stability.

Aberrant expression or mutation of many of the lineage-specific TFs involved in B lymphocyte development have been linked to the outcome of hematopoietic malignancies.

Transcription termination occurs up to several hundred bases downstream of the 3′ end processing site even though both processes are intimately linked and mutation of many 3′ end processing factors results in transcription termination defects [48,76,93,98,102 105].

This is to be expected as rates of mutation of many nuclear genes (especially protein coding) are generally not as high as that typically found in most mitochondrial genes.