Sentence examples for mutations of major from inspiring English sources
Nevertheless, these studies are limited by the sensitivity of the experimental methodologies, which lack the power of detecting small mutational effects and have, instead, proven to be more effective at discovering mutations of major phenotypic impacts.
At one end of the clonal spectrum, we have mutations of major effect that dominate the fitness of the clone they are adopted by.
Within families, whole-exome sequencing (WES) has proven to be effective in uncovering rare causal mutations of major effect in small sample sizes, and is considerably less expensive than whole-genome sequencing.
The reduced fruit set in small patches, the mean self-compatibility index of 0.71 and its variability between individuals (CV of 47%) suggest that ID acted early on fruit set in small patches [ 52– 54] and was probably mediated by a small number of few mutations of major effect.
To facilitate cost-effective growth, vaccine strains are serially passaged under production conditions, which frequently results in mutations of the major antigenic protein, the viral hemagglutinin (HA).
Most of the other BC types observed in the 2005 2006 season were within one or two mutations of this major BC type, suggesting that these might have been derived from AADFAA through mutations during the 2005 2006 season.
Analysis of mutation frequencies of different signalling pathway components showed that several classical CRC-related pathways were significantly mutated in CRC (figure 4A). Figure 4B illustrates the mutation frequencies of major signalling components in Wnt/β-catenin signalling, ErbB signalling, TGF-β signalling and DNA damage sensing and repair.
Gly61 → Cys mutation was of major importance as it diminished the capacity of cells to reorganize keratin filament.
Our data shows that mutation of the major IGF binding site of human IGFBP-2 completely abolished its biological activity in this in vivo animal model.
This hypothesis was verified for B23 by mutation of the major site of CK2 phosphorylation (Louvet et al. 2006).
RNA processing can be improved by mutation of the major and minor HIV-1 splice donor sites in the vector.
