Sentence examples for mutations of largest from inspiring English sources

This is consistent with our intuition that as the population size grows larger, we increasingly expect the mutations of largest effect to dominate the dynamics.

If we think of this as a genetic screen for mutations causing a specific phenotype, with demonstrated saturation mutagenesis of the human population [ 32], then the most effective approach to follow up these discoveries is clear: find the mutations of largest effect and use these as entry points to elucidate the underlying biology.

Most mutational variance appears to be attributable to a few mutations of large effect in, for example, Drosophila (e.g., Bürger 2000 and references therein).

Do changes between species occur through single mutations of large effect, or do they appear incrementally, through the collaboration of many mutations at many different loci?

We discuss how state-of-the-art methods are uncovering a range of genetic mechanisms, from rare mutations of large effect to common polymorphisms that increase risk in a subtle way, while converging on neurogenetic pathways that are shared between distinct disorders.

This theory predicts that with substantial gene flow between populations local adaptation should proceed primarily through mutations of large effect or tightly linked clusters of smaller effect loci.

Indeed, many small populations, both in the experiment and in the simulations, faced handicaps consistent with their diminished access to beneficial mutations of large effect.

It has long been known that deleterious mutations increase VE in certain circumstances, e.g., under inbreeding ([4], p. 289) and in genotypes with known mutations of large effect [5], [6].

Further studies at the genomic scale are required, examining individuals with extreme phenotypes, as the power of whole genome sequencing promises to identify not only mutations of large effect, but also target genes that can be utilized for the development of customized pharmacologic interventions.

Therefore, more mutations, and especially more mutations of large effect, would be adaptive.

The classic paradigm is that resistance evolution occurs by a few mutations of large effect.