Sentence examples for mutations of functional from inspiring English sources

In man, the loss of a functional GLY1 gene appears to be a more ancient event than the loss of TDH because GLY1 genes in both man and chimpanzees have a number of frame-shifts and mutations of functional amino acid residues, whereas the mutated exon 6 splice-acceptor site in human TDH is intact in chimpanzees (data not shown).

Tumorigenesis is caused by unregulated growth of cells resulting from DNA damage, mutations of functional genes, dysregulation of the cell cycle, and loss of apoptotic function [ 10].

To determine whether perturbation of any given gene in a genome suffices to drive subsequent genetic changes, we analyzed the yeast knockout collection for secondary mutations of functional consequence.

Mutations of functional residues usually decrease enzyme activity but often increase stability at the same time [32], [33].

Thus, mutations of functional exonic or intronic sequences would be selected against as they are more likely to reduce the fitness of the individual.

CNV and deleterious mutations of functional CYP2D6 genes are categorized into four phenotypes based on their ability (rate) to metabolize drugs: A poor (PM), intermediate, efficient (EM), or ultrarapid metabolizer (UM) (Zanger et al. 2004).

Tumorigenesis is caused by uncontrolled cell growth resulting from DNA damage, the mutation of functional genes, a dysregulation of the cell cycle, or the loss of apoptotic functions [ 17].

In human cells, retrotransposon activity is believed to be suppressed to restrict the potentially harmful effects of mutations on functional genome integrity and maintenance of genomic stability.

We discuss in detail the two new examples of DUF3050 and DUF2071 in the section on 'Highlights' and 'Enormous divergence and mutation of functional residues during evolution'.

Biochemical and functional analysis indicated these mutations were loss of functional mutations [ 7].

Accordingly, mutations and expression analyses demonstrated distinct molecular signatures associated with mutations of specific functional domains.