Sentence examples for mutations of essential from inspiring English sources

A considerable part of these diseases were resulted from the inherited mutations of essential genes expressed in these retinal cells.

But instead of having a lethal effect (as many mutations of essential genes do), it simply made the flies better "musicians" by allowing them to buzz and chirp with their wings at a higher frequency than those who lacked the mutation a desirable trait in the world of fruit fly courtship.

However, our results suggest that Tus indeed contains a putative NLS signal and that mutations of essential amino acids in this sequence completely abolished nuclear targeting.

Alter, G. M. et al. Mutation of essential catalytic residues in pig citrate synthase.

This absence of a system for genetic complementation of deletion (or mutation) of essential genes from MVA derives in large part from the fact that MVA is routinely propagated on primary CEFs, which, due to their finite lifespan in culture, are not suitable for long-term (multi-passage) genetic complementation.

On the other hand, increased autophagy contributes to longevity, and mutation of essential Atg genes prevents the gain of longevity (Meléndez et al., 2003).

A tendency for mutation of essential genes to more readily cause genome instability is consistent with a previous study that similarly used both essential and nonessential mutant collections (Stirling et al. 2011).

Could it be that an episode of increased mutation and rearrangement rates is at the origin of the emergence of male-sterilizing factors in beet, being either new ORFs through intragenomic recombination as generally assumed (Chase 2007) or the outputs of deleterious mutations on essential mt genes positively selected as they disrupt pollen production (Budar et al. 2003)?

However, it has been difficult to relate the major changes wrought by mutations of developmentally essential genes to the quantitative changes seen amongst natural groups of grasses.

Further support for this hypothesis came from studies involving strains carrying temperature-sensitive mutations of the essential PI/PC transport protein, Sec14.

The observations are interesting in terms of basic principles, since they show that there are apparently several ways of stabilizing Rab GEF complexes via interactions with the P-loop lysine (in one case 2 different ways for the same Rab), but they are probably most interesting with respect to the use of mutations of the essential glutamine for cell biological studies.