Sentence examples for mutations of epigenetic from inspiring English sources

We identified frequent mutations of epigenetic modifiers, most notably mutations of DNMT3A, in 33% of adult MPAL patients.

Moreover, the mutations of epigenetic modulator genes have been shown to be implicated in neuropsychiatric disorders, such as autism spectrum disorders.

► Mutations of epigenetic enzymes are frequently associated with cancer.

On the other hand, current genome-wide studies reported mutations of epigenetic modifier genes encoding proteins that regulate the chromatin structure of cells.

Notably, mutations of epigenetic modifier genes (EMGs), such as DNMT3A (0.3%), TET2 (4.5%), IDH1 (0.4%), IDH2 (0.2%) and ASXL1 (1.6%), could co-exist with PML– RARα fusion, whereas no PTD mutation or fusion of MLL was noted in any cases, suggesting a mutual exclusivity between MLL abnormalities and the PML– RARα characteristic of APL.

First, alterations of epigenetic patterns such as aberrant DNA methylation could arise stochastically due to loss of fidelity or mutation of epigenetic enzymes [109].

Along this line of cooperating mutations on epigenetic genes, we also found in our CNL patient mutated copies of ASXL1 and TET2 genes.

The identification of specific downstream targets exhibiting aberrant epigenetic marks in response to mutation of an epigenetic regulator will have an important impact on our understanding of the molecular pathogenesis of ID.

According to one model, an epigenetic event, such as hypermethylation of a CpG-rich promoter region of a TSG, occurs randomly due, for example, to loss of fidelity or mutation of an epigenetic enzyme.

The mouse skin model of multistage carcinogenesis has demonstrated that cancer development results from the coordination of genetic mutation and alterations of epigenetic factors, including the machineries regulating cell proliferation and apoptosis (Hecker 1987; Zoumpourlis et al. 2003).

In the last three years, next generation sequencing has been used for mapping of epigenetic mutations [ 19], identification of spontaneous mutations [ 20], or for evolutionary considerations [ 21] in yeast.