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This study further suggests that the rate differential between the first one or two with the remaining cell divisions can differ for mutations of different nature (here different lethalities).
Finally, lifelong event-free survival rates estimated using the Kaplan-Meier method did not reveal significant differences in terms of major events between patients carrying mutations of different desmosomal genes (P =.352; Figure 2).
When this is complete, we will have a more complete view of how mutations of different types impact different paths and patterns in evolution.
In other patients, somatic mutations of different driver genes can substitute for acquired missense DDX41 during progression.
Although statistical methodology has been developed for the analysis of genomic data, little is known about the performance of SNP association studies when trying to capture variability from QTL mutations of different ages.
The operational consequences of simultaneous mutations of different sites can be investigated as well: three different mutant couples (ROtx m, (UIOtx m and (UIR m are generated by setting (R = 0, Otx = 0), (UI = 0, Otx = 0) and (UI = 0, R = 0) respectively.
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Homoplasy is the recurrence of mutations on different branches of the mtDNA phylogeny in different parts of the world.
These data indicate that the genetic heterogeneity observed in familial CCM may reflect mutation of different molecular members of a coordinated signaling complex.
Mutation of different residues to alanine (Ser1512, Ser1568, Thr1686, Ser1694, Ser1780) either individually or in combination did not suffice to affect TRPM7 autophosphorylation or activity towards myosin II (Suppl. Fig. S3).
Single proline mutation and acidic to basic mutation of different interacting residues followed by individual GOLD runs explored the importance of Ser520 and Asp522.
In model organisms, evidence has been found both for [ 12, 33, 74] and against [ 34, 35] a role for recombination, in the mutation of different types of microsatellite.
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