Sentence examples for mutations of components from inspiring English sources

They may also be relevant to other laminopathies that are associated with perturbations or mutations of components of the nuclear lamina.

Recent evidences suggested that although mutations of components of the Wnt/β-catenin pathway generally occur early in colon cancer progression, accumulation of β-catenin in the nucleus has been associated with late stages of tumor progression and the development of metastasis [ 17- 19].

Mutation of components of this pathway results in cryptic transcription initiation within the coding region of approximately 30% of yeast genes.

While it is well known that mutation of components of the Set2-Rpd3S produce producryptictranscriptsipts, co-activators that affect transcription from cryptic promoters have not been well characterized.

Since mutation of Ptpn6, which associate with Siglecg orthologue Siglec 10, enhanced NFκB activation and expanded B1a compartment [6], and since mice with targeted mutation of components in NFκB pathway show selective reduction of B1a B cell compartment [8], we focused on the potential impact of Siglecg deletion on NFκB activation.

Mutation of components in the parallel cell-death induction pathway in addition to vib-1 mutations would ameliorate cell death and HI completely, regardless of the presence or absence of ime-2.

Mutation of components of the BAF complex have been found in 20% of all cancers resulting typically in loss of function pointing to tumor suppressor roles of the BAF complex [ 50].

Subsequently, deregulation or mutation of components of the canonical and non-canonical arms of the Wnt pathway were linked to hematopoietic cancers such as acute myelogenous leukemia (AML) [ 48] and solid tumors including breast cancer [ 49, 50], ovarian cancer [ 51], and NSCLC [ 52], among other malignancies.

The genomic structures of HPVs in vaccines (e.g., inactivated high potency particles) could disturb host tissues in a variety of mechanisms (e.g., mutations of DNA components or integration into host chromosomes and instability of genomic substructures).

Mutations of ESCRT components affect differently the formation of CUPs.

Inactivation or mutations of some components of the pathway were identified in different types of cancer.