Sentence examples for mutations of codon from inspiring English sources

The hypothesis of a preferential association of CUPs with mutations of codon 181 deserves further investigations.

Mutations of codon 61 were identified in two patients only, whereas four patients were found to have BRAF (V600E) mutations.

The hypothesis of a preferential association of CUPs with TP 53 mutations of codon 181 deserves further investigations.

Somatic mutations of codon 134 in FOXL2 are reported in 94% of adult stromal granulosa cell tumors.

However, the clinical activity of BRAF inhibitors in patients with rare mutations of codon 600 and the surrounding codons has not been documented.

It would be interesting to investigate additional CUP specimens to know whether mutations of codon 181 occur at a relatively high frequency in this category of malignancies.

Six tumors had TP53 mutations in codons 5 to 8 and 10 tumors from 7 patients had mutations of codons 12 or 13 of K-RAS.

Mutations of codons 500, 538, 539 and 540 in gyrB are also related to resistance to fluoroquinolones.

Thus, the treatment guidelines for selecting patients for anti-EGFR antibodies are unchanged and recommend that patients with any mutations of codons 12 and 13 should not be treated with these therapies.

To detect genetic alterations in K-ras and BRAF, we analysed the point mutations of codons 12 and 13 of the K-ras gene and the mutation of the exon 15 codon 600 of the BRAF gene by direct sequencing using a Big Dye Terminator v3.1, Cycle Sequencing kit, and an ABI Genetic Analyzer 3100.

Because of an amber nonsense mutation of codon 362 (CAG), the IB104 protein ends at residue Pro361.