Sentence examples for mutations of both from inspiring English sources

The FEP simulations on the mutations of both the free-enzyme and transition-state structures allowed us to calculate the mutation-caused shift of the free-energy change from the free enzyme (BChE) to the transition state, and thus to theoretically predict the mutation-caused shift of the catalytic efficiency (kcat/KM).

Mutations of both sites reduced the hydrolyzing activity against highly crystalline β-chitin microfibrils [16].

She pointed out his methods could only identify parentage if offspring had the mutations of both its father and mother, and his data would only be accurate if such offspring were just as viable as those with one or no mutations – which they weren't.

Mutations of both the PHD and kinase domains reduce JNK activation and abrogate MEKK1-dependent apoptosis after cytoskeletal disruption.

Both Pten and Lkb1 play fundamental roles in regulating this pathway, and mutations of both genes are associated with neoplasia.

Mutations of both the TBE1 and TBE2 sites (TBE1/2) dramatically suppressed Wnt3a-stimulated PLD2 promoter activity.

The double mutation of both residues further compromises cation selectivity.

Importantly, this reduction was abrogated by mutation of both proximal and distal Tia1 binding sites (Fig. 5d).

The opening chapter is as scary as they come: is it an eel, is it a man or is it a hideous mutation of both - it's up to young James, the budding secret agent, to find out.

However, mutation of both Ser12 and Ser13 residues to Ala in Delta1-317 completely abrogates activity, while individual substitutions have no effect.

Mutation of both ZFs essentially eliminated partially edited mRNA.