Sentence examples for mutations of all from inspiring English sources

Shields et al. performed single alanine point mutations of all solvent-exposed amino acids in CH2 and CH3 domains of human IgG1.

Mutations of all three RAS genes, N-, H-, and KRAS, are identified mainly in codons 12, 13, and 61 of exons 2 and 3 in human cancers.

Here we propose a generalization to the classical population genetic treatment of pairwise epistasis that yields expressions for epistasis among arbitrary subsets of mutations of all orders (pairwise, three-way, etc).. Our approach reveals substantial higher-order epistasis in almost every published fitness landscape.

We also generated a mutant containing alanine mutations of all 35 mapped residues.

In addition, triple mutations of all three tyrosines to phenylalanines (3Y/F) also inhibit the NLS function even in a kinase-defective BCR63-ABL.

Indeed, the APOBEC and AID enzymes cause mutations almost exclusively in C/G nucleotides, while we observed mutations of all 4 nucleotides (Figure 3).

There were 1,445 small mutations (20% of all mutations), of which 358 (25%) were deletions (smaller than 1 exon) and 132 (9%) were duplications (smaller than one exon); 199 (14%) splice site mutations were recorded.

The most successful genetic mutation of all time has permitted the self-awareness that allows human beings to "empathise, guess, manipulate, out-think, out-fight – and, where necessary, co-operate".

The computational efficiency of our framework was demonstrated with the full-sequence design of the peptide with flexible backbone templates, corresponding to the mutation of all positions except the native cysteines.

These mice carry point mutations in the dystrophin gene and null mutation of all utrophin genes.

Mutation of all residues in either of these conserved sequences undoubtedly prevents correct folding of this domain.