Sentence examples for mutations occurring within from inspiring English sources

A well-defined PARPi resistance mechanism is restoration of HR function via secondary somatic mutations occurring within mutated BRCA1/2 genes, resulting in re-institution of in-frame gene transcription14,15.

We also show how focusing only on significantly mutated genes can miss instances where mutations occurring within a shared domain are actually the more relevant functional contributors to the cancer.

In another early example, Xu et al. performed scWES-seq of 25 single cells by MDA amplification which was used to reconstruct clonal mutations occurring within PBRM1 and VHL in kidney cancer.

Multiple mutations occurring within the same cell cycle and in rapid succession, typically within seconds to minutes [13].

We found a trend towards mutations occurring within CTL epitopes or their flanking regions for the three HIV-1 proteins that were tested (Wilcoxon signed rank test: p = 0.09, with 15 out of 21 samples following the trend).

As above, but restricted to only driver mutations occurring within LOH regions.

Different types of trap mutations occur within the neighbouring region of the W{111} surface.

The vast majority of mutations in the panel result in amino acid changes, but some of the mutations occur within promoter regions.

Many mutations in cardiac troponin T (cTnT) lead to a complex form of HCM with varying degrees of ventricular hypertrophy and ~ 65% of all cTnT mutations occur within or flanking the elongated N-terminal TNT1 domain.

Mutations occurred within noncoding (D-loop) and coding regions.

Four variants associated with sulfite oxidase deficiency have been identified: two mutations are near the sulfate binding site, while the other mutations occur within the domain mediating dimerization.