Sentence examples for mutations occur relatively from inspiring English sources

Interestingly our work also suggests that APOBEC mutations occur relatively early in the development of non-muscle invasive bladder cancer.

ASXL1 truncation mutations occur relatively frequently in CRC cell lines with MSI and in clinical samples of myeloid malignancies (Table 1).

Although activating Ras mutations occur relatively rarely (<5%) in breast cancer, aberrant activation of Ras signaling pathways downstream of growth factor receptors is considered an important driver of the tumorigenic process.

62 Importantly, spontaneous de novo mutations occur relatively frequently; thus, testing for HNF1B mutation should not be discouraged by the absence of a family history of renal disease or diabetes.

When comparing tumours with a missense (but not a truncating) mutation in APC to tumours with a truncating mutation in APC, missense mutations occurred relatively more frequently in the colon (P = 0.002), less often also harboured an activating K-ras mutation (P = 0.004), and more often also lacked hMLH1 expression (P < 0.001).

If the mutation occurred relatively recently, it is possible the minor allele is gradually becoming more prevalent.

Interestingly, G C to C G and G C to A T mutations were also observed in tumours of non-smokers at similar frequencies to G C to T A mutations, suggesting that these mutations can occur relatively frequently in the absence of active smoking.

Mutations in p53 occur relatively late in tumorigenesis (Velho & Haigis, 2011), and thus p53 is not an ideal early somatic mutation target.

We suggest that the same mutations can cause either retinoma or retinoblastoma: benign hyperplastic nodules or retinoma when the mutations occur in relatively mature retinoblasts; and malignant retinoblastoma when the same mutations arise in immature retinoblasts.

This would represent a transitional mutation, and may therefore be expected to occur relatively frequently, but it is highly overrepresented relative to other transition mutations.

Expression of each gene is qualitatively normal at this stage, suggesting that effects of the enz mutation on crest-derived chromatophores occur relatively late in the development of these cell populations (Figure 4C H).