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Gene mutations occur generally because of errors during DNA replication or from exposure to genotoxic agents.
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HCCs occur generally from liver cirrhosis.
The remaining two mutations detected were A T to G C transitions which have also been reported as occurring in other TILLING studies; however, generally these mutations occur at a much lower frequency than the predominant G C to A T mutation [ 30, 32].
Classical linkage analyses are generally not successful as many NDM mutations occur de novo or are not fully penetrant.
Generally, one mutation is not enough to cause cancer; the disease does not develop until other mutations occur.
Most mutations occur when DNA divides.
Mutations occur naturally when cells divide.
So rapidly that lots of mistakes — mutations — occur.
When mutations occur, cells can divide, proliferate and form tumors.
Mutations occur spontaneously, but most organisms have mechanisms that can prevent the damage they might cause.
This means it cannot easily be repaired when harmful mutations occur.
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