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In this study we analysed the expression profiles of GOF mutations obtained from azole-resistant isolates in a previous study [13].
In order to support our assumption, PPCheck was applied on the 10-fold mixed training dataset (192 mutations obtained from ASEdb; 126 mutations obtained from BID) and the EEC of all the interface residues was calculated.
This estimate is reassuringly similar to the estimate of 9.0 mutations obtained from the point estimates used in the simulations.
We therefore looked for polymorphisms that could be used in genetic mapping experiments or to discriminate with mutations obtained from ENU mutagenesis.
Also from synapse, I retrieved the mutations detected in 34 pancreatic carcinoma samples, not included within the datasets of somatic mutations obtained from IntOGen.
The geographic distribution of shared and nonshared mutations obtained from core needle biopsies enabled us to derive common ancestry and clonal evolution within a primary tumor.
Similar(47)
The chromosome carrying the NELF-A[KG] mutation obtained from the Bloomington Stock Center carries an additional lethal mutation as precise excision of the transposon fails to revert the recessive lethal phenotype of the chromosome.
Importantly, mouse Slc39a13 carrying the homologous G to A substitution (G74D, Figures 7C and 7D) as well as human SLC39A13 having the G to A mutation obtained from EDS patients (data not shown) was unable to fully rescue the unresponsiveness of osteoblasts and fibroblasts isolated from Slc39a13-KO mice against BMP and TGF-β, respectively, indicating that this mutation causes a loss of function.
We included drug resistance-mutations obtained from the Tuberculosis Drug Resistance Database (TBDReaMDB) [ 46], and additionally compensatory mutations from [ 47].
P{EPgy2}p53[EY14108] is a P element insert mutation obtained from Bloomington Drosophila Stock Center BLL 20906), and the insertion was mapped to the first exon of the p53 B-variant using inverse PCR (diagrammed in Figure 1B) [ 56].
All six patients with EGFR gene mutations obtained clinical benefit from erlotinib while 2 of 10 patients with KRAS gene mutations derived clinical benefit.
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