Sentence examples for mutations observed to from inspiring English sources

If the genomes were more similar, there would not be sufficient consistent and compensatory mutations observed to infer the presence of base-pairing; if the genomes were less similar, there would not be a good enough alignment to infer structure.

The evolutionary rates of these genes may, however, be too slow for many studies as the number of mutations observed to accumulate between evolutionary branching events can be very low.

We queried the Myriad Genetic Laboratories, Inc. database of approximately 100,000 full-sequence tests to determine the number of times a UV was observed, and the number of different deleterious mutations observed to co-occur with each variant, as a measure of the number of times the UV is seen in trans with a deleterious mutation.

Approximately 52% of the mutations are strongly deleterious (S < −10), comparable with that estimated for humans (Fay et al. 2001) as well as with the fraction of mutations observed to be lethal in experimental studies of vesicular stomatitis virus (Sanjuan et al. 2004) and yeast (Wloch et al. 2001).

The first mutation observed to extend lifespan in the nematode Caenorhabditis elegans, age-1, was discovered through a screen for increased longevity among progeny exposed to chemical mutagenesis [ 1].

Indeed, only point mutations were observed to have accumulated in the epithelial mucosa while the considerably smaller number of mutations accumulated in the serosa were, at least in part, genome rearrangements.

In conventional chondrosarcoma we observe a similar phenomenon, where IDH mutations are present already in a high percentage of low-grade tumors and TP53 mutations are observed to increase with grade (4 5;15).

Rather than suppress the temperature sensitivity of ipl1 mutations, however, the duo1 -2 mutation was observed to be lethal in combination with ipl1 -1 and showed no genetic interaction with ipl1 -2 (Kang et al. 2001).

However, since clones with p16 mutations were observed to have covered an average of 66% of the Barrett's segment, it is unlikely that many alterations were missed.

Frequency of OGG1 mutations was observed to be significantly higher in patients with invasive ductal carcinoma (p < 0.0001), negative ER (p < 0.001), and negative PR status (p < 0.01).

Strikingly, all of the known primary drug resistance mutations were observed to be negatively selected in the Untreated dataset, suggesting that they reduce fitness in the absence of drug treatment [ 29- 31].