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Interestingly, binding site mutations not involved in any direct interaction to the ligands in various cases show significant effects towards their binding thermodynamics.
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The XLPRA1 and XLPRA2 mutations are not involved in this XLPRA, but we cannot exclude the involvement of other mutation in the RPGR gene.
Finally, we provide evidence that periV neurons, the only other group of neurons targeted by the conditional mutations, are not involved in the chemoreflex.
It seems thus that Blau syndrome-related CARD15 mutations are not involved in idiopathic uveitis, a finding which allows us to suggest that the genetic aetiology of the idiopathic uveitis or the Blau-associated uveitis is different.
The stop codon was found to be present in the mammoth as well, suggesting that this mutation is not involved in hair phenotype differences among elephantids.
In a recent article, Xin and collaborators found that the esk1-1 mutation was not involved in drought and salt stress responses [ 32].
This suggests that a host range selection of mutations was probably not involved.
Our data indicate that WAF1/CIP1 mutations are probably not involved in the formation of primary human brain tumours.
On the other hand, three additional single-point mutations that are not involved in any oligomerization interfaces have been discovered in the stalk region.
Overall, it seems that the deleterious effects of the mutations may not involve significant alteration of the coiled-coil structure.
Most mutations will not involve coding genes and will have no selective effect.
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CEO of Professional Science Editing for Scientists @ prosciediting.com