Sentence examples for mutations needs to from inspiring English sources

In addition, intra-tumor heterogeneity with the presence of clones of tumor cells lacking BRAF mutations needs to be considered, since wildtype BRAF can be activated by inhibitors designed to target mutated BRAF.

However, as depression is a complex disorder in which minor changes of many genes as well as environmental factors (including epigenetic programming) play a causal role and determine the phenotype, the use of mice with single gene mutations needs to be critically discussed when attempting to create a genetic animal model of depression.

A standardised method of detecting EGFR mutations needs to be established as soon as possible.

It is dedicated to characterizing variants in clinical settings where only a limited set of relevant mutations needs to be quickly characterized with the highest possible accuracy.

While the clinical relevance of newly identified mutations needs to be further validated, the speed with which cancer genomes can now be sequenced underlines the need for continuous updating of the mutation assays used in the clinics.

However, the functional significance of such mutations needs to be elucidated further because laboratory-generated isolates with similar mutations are rapidly killed by fidaxomicin at 4 times the MICs [ 15].

The resulting distribution will strongly depend on the number of mutational steps analysed, so n different mutations need to be analysed for one measurement of epistasis in order to understand n-step epistasis.

In a purely mutational phylogeny, imperfection corresponds to the number of recurrent mutations needed to explain the data set.

The H5 virus has been present in the human population since the late 1950's, said Dr. Offit of Children's Hospital, but has never acquired the full set of mutations needed to set off a pandemic.

By withholding key details of the mutations needed to make an airborne strain of H5N1, this would give time for governments to prepare for and prevent a possible pandemic, he added.

Depending on their efficacy, safety profile and approval by regulators, oligonucleotides targeting additional exons to address other mutations need to follow, through more tailor-made, shorter, development programs.