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However, the detailed downstream pathways for FUS mediated DDR signaling and its possible disturbance by FUS mutations needs further examination.
Why the DAXX-ATRX interface is not susceptible to disease mutations needs further investigation.
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The potential reasons for lower factor H in renal TMA with lupus nephritis, including autoantibodies against factor H or factor H gene mutations, need further study.
This mutation however needs further evaluation to determine its functional significance.
Understanding the adaptive significance of such mutations in genes needs further experimentation using a larger set of contrasting genotypes.
This result indicates that c.262delG mutation may be a race-specific mutation type, but needs further study with expanded sample size.
Obviously, sensitivity of the RAPD assay depends of the mutations level and it needs further investigations.
Although a small relative risk can be attributed to XRCC2 mutations, the actual association needs further evaluation [ 102, 105].
In our study, 11.8% (9/76) of the samples were also found to be both loss of RASSF1A expression and K-ras mutations in CRC; it needs further studies to verify whether inactivation of RASSF1A has synergistic effect with activated K-ras in CRC.
However, identification of the causative mutation for heart weight needs further investigation.
Although a number of possible genetic mutations has been identified, this area needs further exploration.
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CEO of Professional Science Editing for Scientists @ prosciediting.com