Sentence examples for mutations must occur from inspiring English sources

*In this model, five specific driver genes must be mutated for transformation **In this model, six driver genes must be mutated for transformation, but because multiple genes in the same pathway are functionally equivalent, the mutational target or numbers of base pairs at risk are larger than when mutations must occur in specific driver genes.

We know that mutations must occur, but maybe it's a rare event.

For Knudson's "two-hit" hypothesis, he postulated that mutations must occur in both copies of a gene for the cancer to develop.

After this occurs, an additional C D oncogenic mutations must occur to complete the transformation to a malignant lineage.

After the acquisition of the first D oncogenic mutations, and consequent increase in fitness, an additional C D oncogenic mutations must occur to complete the transformation to a malignant lineage (Figure 1B).

It is likely that additional mutations must occur that cooperate with Trp53 mutation to initiate and drive tumour progression.

For a tumour to form, one random mutation must occur in the healthy RB allele of a retinal cell after conception.

The mutation must occur, therefore, somewhere between the two outermost PstI sites found in the probe region" (L.B., 1997).

The main idea of the author is the Saeptation hypothesis: "initial mutation must occur at some stage which will eventually result in promoting the interbreeding between individuals carrying that mutation rather than with the rest of the population".

But even if it does not result in instant speciation, an initial mutation must occur at some stage which will eventually result in promoting the interbreeding between individuals carrying that mutation rather than with the rest of the population.

In this case, extinction times provide either an upper limit on the time since the origin of selfing or they indicate that some other biological process, such as outcrossing or compensatory mutation, must occur with sufficient frequency to offset genomic decay in the long term.