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This implies that ald mutations must cause meiotic NDJ in mid-to-late prometaphase and prior to the completion of congression.
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Because we have never observed transmission of the eif3e mutation through the male gametophyte [31], it appears that the mutation must cause an additional defect, downstream from pollen tube growth.
"Autism is fairly heritable," he says — which means that inherited mutations must make a "significant contribution".
The criterion for inclusion as an MS gene was that mutation of the gene must cause defects in male reproduction.
Effective melanocyte-toxic therapies must cause vitiligo.
This is because each CIN mutation must ultimately cause or fail to correct one of only a few cellular events (i.e., DNA damage/DNA repair or chromosome non-disjunction).
Furthermore, the preserved enzymatic function of dystonia-parkinsonism causing mutations must be interpreted with caution as there may be differences in PLA2G6 activity in vivo that are not detected by these in vitro assays.
While it is possible that mutations in other genes will result in similar phenotypes, it is clear that NF1 mutations must be the most frequent by far that cause axenic growth.
We know that mutations must occur, but maybe it's a rare event.
The mutated ABCB7 gene is on the X chromosome; in males (XY), one copy of the mutated gene is sufficient to cause the disorder, while in females (XX), a mutation must be present in both copies to cause the condition.
Hundreds of mutations can cause varying degrees of muscular dystrophy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com