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Such studies on the diseasome have focussed on identifying causal mutations, mode of inheritance, their expression across a wide spectrum of tissues and to identify whether they are essential or non-essential genes (i.e. to test their embryonic lethality) [ 1].
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Both the mutation mode and the number of mutations per offspring FSM are with respect to a probability distribution, which means some individual may mutates more than once in one generation. .
Nevertheless this early classification, based entirely on point mutations, was compiled only from two mutation tests; thus, relying on EST sequencing data, it was still not reliable according to our model which incorporated an additional mutation mode.
We call this mutation mode stepwise mutation.
However, the genetic mutation mode in which lung cancer occurred and developed was found to be particularly complicated (Table 4).
When the mutation mode was "step-wise" (see Mutation model section of Methods), speciation never occurred even with high mutation rates.
With the "five sites mutation" mode for opsin gene evolution, the probability of speciation increased with increasing mutation rate (Fig. 2f).
Two dimension histogram of SNV read strand orientation bias (i_ffpe_F) vs. alternate allele counts (alt counts) in the C > T (or complement G > A) mutation mode.
To examine the effect of mutation mode on the results, we also did a simulation in which all mutations shifted the λmax of the visual pigments only by ± 1.
Notwithstanding this deletion excess, when all mutation modes are included, the number of candidate genes is less than 0.5% of the analyzed human genome.
The increasing complexity of models is justified by the underlying processes like inheritance, mutation, modes of reproduction, and spatial subdivision.
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