Sentence examples for mutations might explain from inspiring English sources

Hence, loss of suppression of EGFR signaling by lack of E-cadherin/catenin EGFR intE-cadherin/catenin EGFRes winteractionrmline mutations migHDGCxplain the increased sensitivity to EGfamiliesI3K kinase inhibition in CDH1-deficient HDGC (Fig. 1).

The clinical manifestations are very protean, the residual activity of α-Gal-A and/or different gene mutations might explain different phenotypes, but as yet these concepts have not been proven.

PAH-induced breast tumor mutations might explain any link between air pollution and risk for breast cancer [ 52].

Liss et al. suggest that a heterozygous state for these mutations might explain why patients accumulate 5-oxoproline to a clinically relevant extent in the context of severe stress on the γ-glutamyl cycle [ 5].

If such a substitution sufficiently impairs the AR DNA interaction [33], this loss-of-function mutation might explain the apparent lack of AR responsiveness observed in E006AA cells.

The novel mutation might explain the severity of disease next to typical sequelae of prematurity.

The extra energetic costs of physical information associated with a mutation might explain why identical viral sequences are observed on a global scale.

Noteworthily, no H3.3 mutations were documented in cerebellar HGG, so it is unlikely that a high incidence of the K27M H3.3 mutation might explain the poor prognosis of the cerebellar subset.

The existence of some very-low-level wild-type NDUFA4 transcripts in patients harboring the c.42+1G → C mutation might explain the slower natural history and the comparatively milder clinical phenotype observed; most previously reported patients with nuclear-encoded COX deficiency exhibit severe phenotypes resulting in early childhood death.

To date, investigators studying the genetics of human disease often assume that disease-predisposing alleles are deleterious (Guttmacher and Collins 2002; Bodmer and Bonilla 2008) and that a process of recurrent mutation might explain their presence within the population (Fisher 1958).

The 14th century genome closely resembled those of modern strains and did not have any obvious unique mutations that might explain its unprecedented virulence.