Sentence examples for mutations might exert from inspiring English sources

Yet behavior is the endpoint of neural processing often involving tens or hundreds of cell types in a neural circuit or pathway, and therefore mutations might exert their effects at many places in the brain.

In APL patients treated with ATRA and chemotherapy, these mutations might exert potential impact on the biological behavior, clinical manifestation and treatment outcome (Chan et al., 2006, Rampal and Levine, 2011, Shen et al., 2011).

This mixed motor surface showed a drastic reduction (∼eightfold) in gliding velocities compared to WT alone indicating that the E253K mutation might exert a dominant negative effect over WT KIF1A function in vivo.

On the basis of our findings, the A30P mutation might exert its specific toxicity by impairing autophagy and thereby indirectly increasing intraneuronal αSyn levels among other detrimental consequences of decreased autophagy.

Ted Cohen, an epidemiologist and assistant professor at Harvard Medical School, believes some drug-resistant mutations might not exert the so-called fitness costs that would otherwise compromise XDR TB bacteria and weaken them.

Hence, mutations in TARDBP and FUS indicate that RBPs might exert a central role in the pathogenesis of FTLD/ALS-related disorders.

Mutations found in the middle of the Aβ domain might exert different effects, (1) they might decrease the α-secretory cleavage of APP thereby facilitating amyloidogenic processing of APP [ 27], (2) these mutations could also increase the aggregation [ 28], (3) and/or alter the degradation by different proteases [ 29].

This result helps to explain that the sgg mutation might suppress toxicity by reducing levels of Sgg/GSK-3β and that ksr might exert its suppressive effects by increasing inactivated GSK-3β, as observed in gl-tau flies (Fig.  7B).

However, a previous study in IBD patients suggested that heterozygous carriers of the ΔF508 mutation in the CFTR gene, the main susceptibility gene for patients with cystic fibrosis, might exert a protective effect in CD [49], suggesting opposing effects of genetic risk loci for cystic fibrosis and IBD.

It is unclear how Δ133p53 might exert a beneficial function in the presence of mutant p53.

In the highest dose MPEP might exert anxiolytic properties.