Other microsatellite mutations might be caused by unequal crossing over, nucleotide substitutions, or duplication events [ 7].
The progressive identification of novel mutated genes is expanding the 'cast of actors' [ 14] whose mutations might be causally involved in driving cancer.
Moreover, whole-genome sequencing typically contains mistakes, so key mutations might be missed.
In that case, patients with rare mutations might be left behind.
For the loss of Forssman antigen expression in humans we assumed that missense mutations might be responsible.
We speculated that some DNA mismatch repair germline mutations might be associated with early onset of disease.
A study now explores how clonal expansion of epidermal stem cells with specific oncogenic mutations might be restricted by their elimination through enforced differentiation.
These mutations might be oncogenic thereby increasing cell proliferation or they might abrogate an inhibitors' binding affinity or they might be completely benign.
Any number of mutations might be needed for the virus to take hold in humans, helping it better infect cells, replicate inside them, or evade the immune system.
Synonymous mutations might be expected to have no detectable effect on fitness, as this class of mutation does not change the amino-acid sequence of the encoded protein.
Some of these mutations might be responsible for the skeleton's bizarre form, causing a hereditary disorder never before documented in humans.
