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That is how other influenza strains spread among humans, and both Fouchier and Kawaoka wanted to know which mutations might allow H5N1 to do the same.
Identification of new mutations might allow for the identification of high-risk classes in analogy to the effect of ERG fusion genes [ 65, 66 ].
It might explain normal or borderline ceruloplasmin levels in some WD patients as protein-truncating mutations disrupt any copper-transporting function, while certain missense mutations might allow residual function in holo-ceruloplasmin synthesis.
In a hypothetical situation in which GWASs results in more than 200 loci that are significantly associated with a complex phenotype, validating the effect of the top 20 most important mutations might allow the statistical model to predict the phenotype accurately in more than 95% of unknown strains.
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The K76T amino acid mutation might allow the interaction of PfCRT with the positively charged chloroquine (CQ+ or CQ++) and allow its exit from the vacuole, with the net result of decreasing the chloroquine concentration within the DV [16], [24].
About 3 percent of the tumors had a gene mutation that might allow them to evade the immune system.
In some cases, back mutation of the mutator allele might allow reversion to wild-type mutation rates, such that deleterious alleles would not continue to accumulate indefinitely.
This further suggests that, in TSC, an additional mutation of p53 might allow progression to malignancy.
If these mitigating processes are weak enough, an increase of mutagenic substances in the environment could easily lead to a rate of mutation accumulation that might allow extinction within time frames that are frequently of interest to conservation biologists.
"I suppose if you were making a vaccine against one part of one protein, it might allow mutation, but we don't give it a chance".
Therefore, we inferred that relaxed purifying selection might allow mutation at the miR156 binding sites and produce greater sequence diversity, which contributes to the increasing number of miR156 target genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com