Sentence examples for mutations may prove from inspiring English sources

Thus, ubp1 mutations may prove to play a role in multi-drug resistance, as is the case for mdr1 [ 43].

Our results also suggest that some splice junction mutations may prove useful when reduced, but not complete, loss of gene expression is desired.

The classification of several splice-site variants as true pathogenic mutations may prove useful for genetic counselling of families with high risk of breast and ovarian cancer.

While targeting the individual driver mutations may prove to be futile in pancreatic cancer, focus on targeting commonly deranged pathways such as metabolic pathways, neoangiogenesis, cell cycle regulation, and DNA repair pathways may be the more effective strategy [ 8].

Therefore, a refined knowledge of the effects of these mutations may prove useful for understanding pathways that lead to, or mitigate, long-term health, prevention of cancer and late-stage disease.

The ability to generate conjugates site-specifically based on a single amino acid mutation may prove to be valuable to researchers wishing to investigate structure activity relationships (SAR) on ADCs.

That is, the increased genetic variation which is concomitant with high mutation rate may prove useful under environmental change, assuming that the greater variation affords access to more mutations of beneficial effect.

Identifying driver mutation targets may prove to be the easier part of this process since the ability to sequence the genomes of individual tumour cells, is now possible (Navin et al, 2011; Ruiz et al, 2011; Xu et al, 2012).

These data suggest that these genotype mutation models may prove valuable for the evaluation of therapeutic methodologies suitable for the treatment of human diabetes- or obesity-influenced, LV degeneration-linked human conditions, which demonstrate amelioration from conventional replacement therapies following diagnosis of systemic syndrome-induced LV osteomaturation-associated deformations.

15 Detection of resistance mutations in plasma may prove to be of major importance in the clinical setting, because patients may benefit from adjustments in the treatment regimen.

Despite epigenetic silencing being the dominant mechanism for SMARCA2 inactivation, specific mutations may also prove important in the pathogenesis of certain cancers.