Such cells then carry the risk that subsequent mutations may lead to neoplastic evolution of individual clones.
Functional analysis of these mutations may lead to a better understanding of the disease mechanisms, and even the discovery of new biomarkers and/or drug targets, as well as more rational design of therapeutic regimens.
We describe our current understanding of how these Cu,ZnSOD mutations may lead to aggregation/fibril formation, as a detailed understanding of these mechanisms provides new avenues for the development of therapeutics against this so far untreatable neurodegenerative pathology.
To determine whether BRCA carriers have a decreased ovarian reserve compared with women without BRCA mutations, because BRCA mutations may lead to accelerated oocyte apoptosis due to accumulation of damaged DNA.
And, just like failures of the nuclear genes, such mutations may lead to disease.The sins of the mothersAnimal mitochondria do not actually contain much DNA just the bare essentials, with no frills.
Secondary mutations may lead to nilotinib resistance, similarly to those involved in imatinib resistance.
Furthermore, genome sequencing of the abp1-5 mutant revealed that background mutations may lead to auxin and other phenotypes (Enders et al., 2015).
Nav1.5 mutations may lead to various cardiac diseases such as LQT3 (long QT syndrome 3), BRGDA1 (Brugada syndrome 1), and SSS1 (sick sinus syndrome 1) (Olson et al., 2005; Song and Shou, 2012; Veerman et al., 2015).
Some rare mutations may lead to autism by disrupting some synaptic pathways, such as those involved with cell adhesion.
As splice site mutations may lead to the use of cryptic splice sites, potential splice sites in the vicinity of wild-type splice sites were identified with HSF.
Some mutations may lead to extensive downstream cascades that may be reflected in network patterns that are too broad to effectively pinpoint the disease-causing gene.
