Sentence examples for mutations may indicate from inspiring English sources

Nonsense or frameshift mutations were relatively rare, given that TP53 is a tumor suppressor gene, and the predominance of missense mutations may indicate altered function of TP53 rather than complete inactivation.

Pathogenic mtDNA mutations may indicate for their functional contribution in progression of the tumors.

In the near future, identification of additional mtDNA mutations may indicate further candidate genes for hypertension.

Overexpression of β-catenin and KRAS mutations may indicate that ACF constitute a premalignant stage [ 16].

These frameshift mutations may indicate a loss of function in this gene copy.

Third, the high frequency of trait-increasing mutations may indicate the trait is not actually a fitness component.

Therefore, the fact that ERBB2 amplification is rare in tumors with BRCA1 mutation may indicate that ERBB2 amplification is dependent on mutagenic homology-directed repair.

The relatively small (3 °C) decreases in melting temperature by the quite drastic Asp56 deletion mutation and the R232A/P233G/L234R/D235P four-fold mutation may indicate that these residues are not in a so-called weak spot of the protein that is more sensitive for unfolding (Eijsink et al. 2004), although the higher B-factors had suggested it to be.

The greater potentiation by the S155W mutation may indicate that a larger than normal side chain protruding into an anesthetic binding site accentuates an effect resulting from anesthetic binding, especially with the tryptophan side chain being significantly larger than a single halothane molecule.

Several of the strains contain very few of the R57 mutations, which may indicate that not all R57 mutations are needed for HWSSL tolerance and likely that other unidentified mutations present within the round 5 population contribute to the tolerance trait.

The enterprise, Color Genomics, offers affordable at-home genetic testing for mutations that may indicate a higher risk for hereditary cancers, heart conditions and medication responses.