These restrictive mutations may have fine-tuned how the receptor grabbed cortisol.
Furthermore, it suggests that PTEN and PIK3CA mutations may have additional nonoverlapping consequences during CRC tumorigenesis.
Colon cancers often have KRAS2 mutations and, if not KRAS2 mutations, may have BRAF mutations.
This means that medical knowledge about rare mutations may have to be developed independently for each population.
And six mutations appeared to be present in only a subset of the cells in the primary tumor, suggesting that the cells carrying these mutations may have been selected for as the cancer progressed, eclipsing other cells.
But, say its critics, its clients do not always understand that other mutations may have crept in.And testing has other repercussions.
Although most of TP53 mutations has been described as loss-of-function, it has been proposed that some TP53 mutations may have oncogenic capabilities [206].
Rambaut's hunch is that the mutations may have been introduced when Canadian scientists prepared the isolates for sequencing.
Still other mutations may have arisen spontaneously — a mystery that, in the absence of Ata's parents' genes, will probably endure.
Other functional mutations may have the same extracellular effect.
These two mutations may have been co-operating tumorigenic events.
