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Such recurring mutations may also be necessary to maintain the prevalence of HD in Europe at its relatively high level.
Taken together, these results suggest that these mutations may also be beneficial in more natural environments and are not just an artefact of life in a laboratory environment.
Loss of function mutations in GLIS3 cause neonatal diabetes8 and increased cell death caused by GLIS3 mutations may also contribute to T1D and T2D.
We conclude that the chronic inflammatory state in RA9 may facilitate the acquisition of somatic mutations, and thus, we hypothesize that somatic mutations may also occur in other inflammatory conditions.
Splicing mutations may also play a role in susceptibility to ASD [55 57].
Furthermore, PTRF mutations may also cause cardiac dysfunction accompanied by cardiomyocyte hypertrophy and cardiac fibrosis [10].
Chromosomal mutations may also lead to decreased permeability or overexpression of efflux pumps, resulting in reduced susceptibility.
Despite epigenetic silencing being the dominant mechanism for SMARCA2 inactivation, specific mutations may also prove important in the pathogenesis of certain cancers.
The mutations may also explain why some genes have much different expression levels than would be expected between humans and chimps.
Mutations may also allow the plants to thrive outside of their usual environments of Queensland and the Northern Territory.
These classes of "slightly deleterious" mutations may also result in suboptimal 3R system activity.
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